Morphogens as conserved axon guidance cues.
نویسندگان
چکیده
Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in development.
منابع مشابه
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.
During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins, rather than ...
متن کاملAxon Guidance: Morphogens Show the Way
Hedgehog and Wnt family proteins can act as classic developmental morphogens to pattern a field of nai;ve cells. Surprising new studies show that members of these same protein families also act as guidance cues for growing axons in the developing nervous system.
متن کاملGraded Positional Information Interpretation for Both Fate and Guidance
Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.
متن کاملAxon guidance cues in auditory development.
The innervation of the cochlear sensory epithelium is intricately organized, allowing the tonotopy established by the auditory hair cells to be maintained along the ascending auditory pathways. These auditory projections are patterned by several gene families that regulate neurite attraction and repulsion, known as axon guidance cues. In this review, the roles of various axon guidance molecules...
متن کاملBMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions.
The finding that morphogens, signalling molecules that specify cell identity, also act as axon guidance molecules has raised the possibility that the mechanisms that establish neural cell fate are also used to assemble neuronal circuits. It remains unresolved, however, how cells differentially transduce the cell fate specification and guidance activities of morphogens. To address this question,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current opinion in neurobiology
دوره 17 1 شماره
صفحات -
تاریخ انتشار 2007